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Updated: Jan 9, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
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在actinomycetes中解读静音生物合成基因集群的策略

Mohd Murtaza1,2, Puja Gupta1,3, Poonam Choudhary1,2

  • 1Fermentation & Microbial Biotechnology Division, CSIR-Indian Institute of Integrative Medicine, Jammu, 180001, India.

Archives of microbiology
|December 9, 2025
PubMed
概括

动氨菌具有生产有价值的二次代谢产物的未开发潜力. 这篇评论探讨了CRISPR/Cas和核糖体工程等策略,以激活静音生物合成基因集群 (BGCs),帮助发现新的抗生素来对抗抗菌素耐药性 (AMR).

关键词:
动态菌株. 动态菌株. 抗微生物耐药性 抗微生物耐药性 生物合成基因群.生物合成基因群. 这就是CRISPR/CasPR.计算生物学是一种计算生物学.自然产品是天然产品.沉默的基因集群

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