乳酸细菌:狗狗幼犬配方中的潜力
Natalia Carrasco1, María Hortencia Miranda1, Cecilia Aristimuño Ficoseco1
1Centro de Referencia para Lactobacilos (CERELA-CONICET-FML-FECIC), San Miguel de Tucumán, Chacabuco 145, CP4000, Argentina.
Veterinary research communications
|December 9, 2025
概括
这项研究评估了犬类益生菌菌株的安全性和有效性. 四种兼容的菌株,即Lactobacillus johnsonii 67,Lactiplantibacillus plantarum 74,Ligilactobacillus salivarius 84和Pediococcus acidilactici 81,已被选择用于一种新的犬类益生菌配方.
科学领域:
- 伴侣动物卫生动物健康
- 微生物学 微生物学
- 兽医益生菌 兽医益生菌
背景情况:
- 益生菌和营养保健品在兽医中越来越受欢迎,作为抗生素的替代品.
- 抗生素带来风险,包括细菌耐药性和肠道微生物生态的破坏.
- 需要为伴侣动物提供安全有效的益生菌配方.
研究的目的:
- 评估隔离的有益的犬类益生菌菌株的体外安全性和技术特性.
- 为了确定适合用于狗的多菌株益生菌配方的菌株.
主要方法:
- 选100只犬类隔离物以检测抑制物质的产生,使用板式扩散.
- 在实验室中对30种预先选择的菌株进行安全性评估,包括抗生素耐药性和毒性因子分析.
- 对10个选定的菌株进行了对胃肠道状况,热量和溶液度的耐受性以及菌株间兼容性的评估.
主要成果:
- 一些菌株表现出对常见病原体的抑制活性;38%的菌株产生过氧化 (H2O2).
- 抗生素耐药性基因仅在一种菌株中发现;没有检测到凝酶或莱西酶活性.
- 对应激条件的耐受性因菌株而异;乳酸菌 johnsonii 67,乳酸植物菌 plantarum 74,乳酸菌 salivarius 84和Pediococcus acidilactici 81已经证明了它们的兼容性.
结论:
- 精选的犬类益生菌菌株具有理想的体外安全性和技术性质.
- 四种兼容的菌株 (L. johnsonii 67,L. plantarum 74,L. salivarius 84,P. acidilactici 81) 适合用于多菌株的犬类益生菌配方.
- 开发的益生菌配方需要在体内进行进一步的评估.
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