进化我们对维生素D,皮奥斯水平和老年人心血管风险的理解:一个横截面研究
Maria Luisa Brandi1, Francesca Marini2, Simone Parri2
1Fondazione FIRMO Onlus (Fondazione Italiana Ricerca Sulle Malattie Dell'Osso), Via San Gallo, 123-50129, Florence, Italy. marialuisa@marialuisabrandi.it.
概括
低水平的维生素D和蛋白质皮奥斯与老年人心血管风险增加有关. 这些发现表明,维生素D和环素可能有助于识别老年人群中心脏病风险.
科学领域:
- 老年学是指老年学的学科.
- 心血管健康 心血管健康
- 营养生物化学 营养生物化学
背景情况:
- 心血管疾病 (CV) 的风险随着年龄的增长而增加.
- 维生素D和环素与心血管健康有关.
- 了解它们的相互关系可能会揭示衰老中心血管风险的机制.
研究的目的:
- 为了探索维生素D,皮奥斯和老年人心脏病风险之间的关系.
- 确定这些标志物是否可以帮助识别老年人群中的心血管风险.
主要方法:
- 来自InCHIANTI生物库的老年参与者的横截面分析.
- 测量血清中的25-氧维生素D (25(OH) D),1,25-二氧维生素D (1,25(OH) 2D) 和质素.
- 使用回归分析评估与心血管风险得分 (任意和SCORE2/SCORE2-OP) 的关联.
主要成果:
- 在皮奥斯和维生素D代谢物 (25(OH) D和1,25(OH) 2D之间发现了显著的正相关性.
- 低质素的个体表现出显著更高的心血管风险得分和SCORE2/SCORE2-OP值.
- 在多变量分析中,低的1,25(OH) 2D水平仍然与高心血管风险有显著的关联,独立于质素.
结论:
- 在老年人中,皮奥斯和血清维生素D水平之间存在显著的关联.
- 低维生素D和低皮奥斯都与心血管风险增加有关.
- 这些标志物可能在老年人心血管疾病的发展中发挥作用.
相关概念视频
Role of Vitamins in Maintaining Bone Health
4.9K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
4.9K
Role of Skin in Vitamin D Synthesis
7.4K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
7.4K
Connective Tissue Cell Types
4.0K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
4.0K
Bone Disorders
5.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.0K
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
358
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
358
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
176
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
176

