脊椎骨分数和心血管结果之间的关联:一个人口层面的历史队列研究
Carrie Ye1,2, Didier Hans3, John T Schousboe4,5
1Department of Medicine, University of Alberta, Edmonton, AB, Canada. cye@ualberta.ca.
概括
骨质疏松症查期间的腰椎下部脊柱骨评分 (TBS) 预测了主要的心血管事件,如心脏病发作和中风. 这一发现确定了TBS作为一个新的心脏病风险因素在评估骨健康的个体.
科学领域:
- 骨质疏松症和心血管疾病研究
- 评估骨健康和心脏风险评估.
背景情况:
- 骨质疏松症和心血管疾病都有共同的风险因素,这导致两者都存在不理想的风险分层.
- 从骨矿物密度 (BMD) 测试中得出的腰椎椎间板骨分数 (TBS) 用于骨折风险评估.
- TBS补充了传统的心血管风险因素.
研究的目的:
- 评估腰椎脊柱骨评分 (TBS) 对主要不良心血管事件 (MACE) 的预测能力.
主要方法:
- 一项人口层面的队列研究包括66 572名40岁及以上的个人.
- 使用双能X射线吸收度 (DXA) 扫描测量腰椎TBS.
- 事件MACE (急性心肌梗塞,中风,全因死亡率) 通过行政数据库进行了跟踪.
主要成果:
- 在9.5年的随访期间,22.3%的个人经历了MACE.
- 降低TBS显著与MACE风险增加有关 (HR为每SD降低1.13).
- 这种关联即使排除了先前患有心血管疾病的个人,也仍然显著.
结论:
- 脊椎骨评分 (TBS) 被确定为一种新的心血管风险因素.
- 在接受骨质疏松症评估的个体中,TBS可以提高风险评估.
- 低TBS可能表明对心血管事件的敏感性增加.
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