在人类肠道微生物群中的Akkermansia muciniphila菌株水平动态
Na Han1, Xianhui Peng1, Tingting Zhang1
1National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
AMB Express
|December 9, 2025
概括
Akkermansia muciniphila (Akk) 的丰富性在肠道中波动,不同的菌株殖民并在人与地区之间传播. 了解Akk动态是肠道健康研究的关键.
科学领域:
- 微生物组研究的研究.
- 肠道健康 肠道健康
- 细菌生态学 细菌生态学
背景情况:
- 阿克尔曼西亚 (Akkermansia) muciniphila (Akk) 是一个关键的肠道细菌,影响肠道健康.
- 它的人口动态和菌株多样性尚未完全理解.
研究的目的:
- 为了研究时间动态,菌株多样性和阿克克曼西亚 (Akkermansia muciniphila) 的传播.
- 分析来自中国微生物组项目 (CMP) 的纵向元基因组数据.
主要方法:
- 从7个健康个体在52个时间点进行长度元基因组测序 (16S rRNA和全基因组测序).
- 对Akkermansia元基因组组装基因组 (MAG) 和公开可用的菌株进行基因组分析.
- 用平均核酸标识 (ANI) 来评估菌株相关性的植物遗传学分析.
主要成果:
- 观察到阿克克相对丰度的显著波动,包括"短期开花".
- 鉴定出了基因组学上截然不同的阿克克群,个人随着时间的推移拥有不同的群,这表明了菌株的替代.
- 在同居的个体之间以及在地理上遥远的地区之间共享了高度相似的阿克克菌株.
结论:
- Akkermansia muciniphila在人类肠道中表现出动态的时间变化和显著的菌株水平多样性.
- 不同的阿克克集群的菌株替代和反复殖民发生在个体中.
- 人间和环境传播途径促进了阿克克菌株在人口和地区的传播.
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