基于表面的,但不是基于voxel的形态学揭示了主观认知衰退的个体的结构异常
Laura Serra1,2, Sabrina Bonarota2, Carlotta Di Domenico2,3
1Department of Human Sciences, Università degli Studi Guglielmo Marconi, Rome, Italy.
Journal of Alzheimer's disease : JAD
|December 9, 2025
概括
主观认知衰退 (SCD) 显示早期皮质变化,与阿尔茨海默病 (AD) 的体积损失不同. 先进的MRI可以检测到这些微妙的结构差异在认知问题的人.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 阿尔茨海默氏症疾病研究研究
背景情况:
- 主观认知衰退 (SCD) 描述了没有客观缺陷的认知衰退,可能表明早期阿尔茨海默病 (AD).
- 了解SCD中的结构性大脑变化对于早期AD检测和干预至关重要.
研究的目的:
- 为了比较SCD患者的灰质 (GM) 量和皮质折叠与更广泛的AD频谱.
- 用先进的MRI技术研究SCD早期结构性大脑变化.
主要方法:
- 107名参与者 (AD,无记忆症轻度认知障碍[aMCI],SCD,健康对照[HS]) 接受了神经心理测试和3T MRI.
- 基于voxel的形态测量 (VBM) 和基于表面的形态测量 (SBM) 用于通过CAT-12分析T1加权的MRI数据.
主要成果:
- 与SCD和HS相比,VBM显示了AD和aMCI的显著缩;在SCD和HS之间没有发现GM体积差异.
- 在所有测量标准中,SBM显示了阿尔茨海默病患者皮质表面异常.
- aMCI患者表现出皮质厚度和缩的减少;与HS患者相比,SCD患者表现出缩和深的减少.
结论:
- 皮层表面异常可能会在AD连续体的体积变化之前发生.
- 多参数MRI可以检测SCD中的微妙结构变化,有助于早期AD频谱的识别.
- 需要进一步的研究来探索这些发现的早期干预策略在AD.
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