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野生灵长类动物 (Theropithecus gelada) 早期感染动态和腺病毒的基因组多样性

Maya J Saroff¹, Abebaw Azanaw Haile², Alice Baniel³

¹School of Life Sciences, Arizona State University, Tempe, AZ, USA.

Microbial genomics

|December 9, 2025

概括

果拉达中的腺病毒 (AdV) 显示出与人类不同的早期生命动态. Simian adenoviruses (SAdVs) 在社交游戏开始之前感染婴儿,在他们的寿命中风险会下降.

科学领域:

灵长类病毒学
免疫学免疫学免疫学
进化生物学进化生物学

背景情况:

人类腺病毒 (AdVs) 引起呼吸系统疾病,特别是在儿童和免疫功能低下的人群中.
传播发生在通过便-口腔和空气传播的密切接触环境中.
早期生命中的腺病毒动态在非人类灵长类动物中尚不清楚.

研究的目的:

为了研究类腺病毒 (SAdV) 动力学,跨越格拉达的寿命 (Theropithecus gelada).
为了确定SAdV在野生灵长类动物群体中存在和丰富的驱动因素.
为了比较早期的AdV感染模式在果拉达和观察到的人类.

主要方法:

从埃塞俄比亚的格拉达种群收集纵向数据.
从便样本中识别编码完整的AdV基因组.
影响SAdV感染的行为和季节性因素的评估.
分析不同年龄组的SAdV存在和丰富性.

主要成果:

确定了十个编码完整的SAdV基因组,其中包括四个新物种.
与预期相反,在6个月以下的婴儿中,SAdV感染的可能性最高.
随着年龄的增长,SAdV的风险和丰富性下降,成人感染很少.
较高的最低温度显示,与SAdV丰富度的负相关性较弱.

结论:

与人类不同,Geladas中的SAdV暴露发生在社交游戏开始之前,可能是由于近距离接触.
生命早期的SAdV感染可能会赋予格拉达的终身免疫力,类似于人类的AdV.
在两种物种中,SAdV的流行率在成年期仍然很低.

关键词:

亚第诺病毒idae 的泰罗皮塞克斯格拉达 (Theropithecus gelada) 是一个的动物.格拉达斯 (Geladas) 是一种冰淋.婴儿时期的婴儿时期.转基因组学是指转基因组学.灵长类的病毒组.

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