红中的点多糖类通过调节肠道微生物群和肝脏代谢来预防代谢功能障碍相关的脂肪肝疾病的发展
Suisui Jiang1, Chunyun Lu1, Chunhui Zhao1
1School of Public Health, Qingdao University, Qingdao 266071, China.
Journal of agricultural and food chemistry
|December 9, 2025
概括
卡斯卡拉果多糖 (CPP) 通过提高烟酸盐水平和改善胆固醇清除来缓解脂肪肝疾病. 这种益生菌剂在通过肠道微生物群调节来管理代谢功能障碍相关的脂肪肝疾病 (MAFLD) 中表现有前途.
科学领域:
- * 营养科学 营养科学
- * 生物化学 * 生物化学
- * 微生物学 微生物学
背景情况:
- *代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是与脂质代谢障碍相关的日益严重的健康问题.
- *含有丰富的拉姆诺加拉克图龙I的花粉中的素多糖体显示出对脂质代谢调节的潜力.
- *饮食干预对于管理MAFLD至关重要,突出显示了对新型治疗剂的需求.
研究的目的:
- * 为了研究卡斯卡拉果多糖 (CPP) 的物理化学特性.
- * 评估CPP在改善高脂肪饮食引起的MAFLD方面的疗效.
- *阐明CPP作用的潜在分子和肠道微生物群机制.
主要方法:
- * CPP物理化学性质的表征.
- * 给高脂肪饮食 (HFD) 的CPP诱导MAFLD小鼠模型.
- *分析肝损伤,肝脂水平,肠道微生物群组成和关键代谢途径 (例如,烟酸代谢,AMPK信号传递).
- *分子对接用于预测烟酸和AMP激活蛋白激酶α (AMPKα) 之间的相互作用.
主要成果:
- * CPP显著缓解了HFD诱导的MAFLD中的肝损伤和肝肥胖症.
- * CPP治疗通过降低酸酸酶的调节和减少蛋白质细菌的数量,增加了烟酸盐水平.
- *分子对接证实了烟酸和AMPKα之间的直接相互作用.
- * CPP通过AMPK-FOXO3a-PCSK9-LDLR通路促进胆固醇的清除.
- * CPP通过肠道微生物群-代谢物-脂质轴减轻了HFD诱导的肝肥胖症.
结论:
- *卡斯卡拉果多糖 (CPP) 显示出对MAFLD的显著治疗潜力.
- * CPP通过调节肠道微生物群,增加烟酸和激活AMPK信号通路来调节脂质代谢而起作用.
- * CPP代表了一种有希望的,可持续的益生菌剂,用于MAFLD管理中的饮食干预.
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