个性化脊侧前额叶皮层神经调节对精神分裂症谱系障碍的默认模式连接和工作记忆的影响
Stéphanie Grot1, Luigi De Benedictis1, Alan Bougeard2
1Research Center of the Montreal University Institute for Mental Health, Montreal, Quebec, Canada; Department of Psychiatry and Addictology, University of Montreal, Montreal, Quebec, Canada.
Psychiatry research. Neuroimaging
|December 9, 2025
概括
个性化经磁刺激 (TMS) 在精神分裂症谱系障碍中没有改善工作记忆. 针对特定的大脑连接模式可能需要更多的数据来进行有效的认知增强.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 精神病学是一个精神病学.
背景情况:
- 精神分裂症谱系障碍 (SSD) 涉及工作记忆缺陷和异常的大脑连接.
- 跨磁刺激 (TMS) 可以调节大脑连接,但往往缺乏个性化的准.
- 功能网络拓的个体变化使TMS的有效性复杂化.
研究的目的:
- 研究个性化与标准化的TMS协议在调节大脑连接和改善SSD患者工作记忆方面的有效性.
- 探索基线功能连接和TMS诱导的变化之间的关系.
主要方法:
- 22名SSD患者接受了20Hz的重复性TMS,针对个性化的CEN-DMN对抗或标准化的F3站点.
- 休息状态fMRI和工作记忆评估在TMS前后进行.
主要成果:
- 无论是个性化还是标准化的TMS都没有显著改变CEN-DMN连接或改进工作内存.
- 生物标志物的低可靠性可能影响了个性化准的有效性.
- 较高的基线DMN网络内部连接与降低的CEN-DMN连接和改进的工作内存相关.
结论:
- 目前针对SSD的个性化TMS准可能受到生物标志物的可靠性和不足的fMRI数据的限制.
- 未来的研究应该集中在获取更多的fMRI数据以准确识别目标.
- 针对具有更高DMN连接的左前额区域显示了调节功能连接和增强SSD中的工作内存的潜力.
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