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从空气中的颗粒物中通过皮肤吸收金属:评估皮肤屏障完整性的作用

Giovanna Marussi¹, Francesca Larese Filon², Marta Baldassar³

¹Unit of Occupational Medicine, Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy; Department of Chemical and Pharmaceutical Sciences, University of Trieste, Trieste, Italy.

The Science of the total environment

|December 9, 2025

概括

城市颗粒物 (PM) 通过皮肤吸收金属是一个令人担忧的问题. 损坏的皮肤显著增加金属的透,,和构成最高的风险.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
皮肤病学皮肤病学

背景情况:

空气中的颗粒物 (PM) 构成健康风险,其中金属含量是关键问题.
吸入是主要的暴露途径,但PM相关金属的皮肤吸收尚未研究.
城市道路灰尘含有各种金属,具有潜在的毒理作用.

研究的目的:

研究城市道路灰尘中的金属通过人体皮肤的体外穿透.
评估皮肤完整性 (完好或磨损) 对金属皮肤吸收的影响.
为了评估颗粒物中存在的特定金属的皮肤生物可用性.

主要方法:

人体皮肤样本被暴露在城市道路灰尘 (NIST SRM® 1649b) 中,在使用弗朗茨扩散细胞的人工汗水中.
在24小时内测量金属透率,用于完整和磨损的皮肤状况.
通过扫描电子显微镜和金属溶解性测试进行了颗粒大小分析.

主要成果:

没有检测到 (Cd), (Cr) 和铜 (Cu) 的皮肤吸收.
磨损皮肤显著增强了 (As), (Mn), (Mo), (Ni), (Pb) 和 (V) 的透.
(Ni), (Pb) 和 (Mn) 在受损皮肤中显示出最高的透水平.

结论:

皮肤屏障的破坏促进了PM相关金属的皮肤运输.
对颗粒物中的某些金属的皮肤暴露是相关的途径,特别是在受损皮肤的情况下.
环境健康风险评估应考虑颗粒物中的金属的皮肤吸收.

关键词:

皮肤暴露皮肤暴露弗朗茨的扩散细胞.重金属是一种重金属.人的皮肤人的皮肤城市尘埃城市尘埃

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