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一个强大的金属离子干扰疗法的激动剂:多个细胞死亡程序来放大瘤金属免疫疗法

Yechen Huang¹, Li Wang¹, Jie Wu¹

¹Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, 215123, China.

|December 9, 2025

概括

一种新型的双层氧化复合物,ZCA-LDH@DSF,有效地输送和铜离子,触发多种细胞死亡途径,如cuproptosis和pyroptosis,以加强癌症治疗.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
在瘤学瘤学.

背景情况:

金属离子干扰疗法 (MIIT) 通过诱导细胞死亡,显示出癌症治疗的前景.
挑战包括多个金属离子的高效传递和细胞电阻.
开发新的交付系统对于推进MIIT至关重要.

研究的目的:

构建一个新的MIIT发起器,以高效地联合输送多个金属离子.
为了增强金属离子的细胞内保留,并克服细胞抵抗.
研究联合输送的离子和药物对癌细胞死亡的协同效应.

主要方法:

用二硫 (DSF) 装载的 ZnCuAl 层双氧化物 (ZCA-LDH@DSF) 复合物的制造.
在酸性环境中对Zn²⁺,Cu²⁺和DSF的pH反应释放的评估.
对Cu2+/DSF (CuET),Cu2+过载 (cuproptosis) 和 Zn2+ (pyroptosis) 对癌细胞的联合影响的评估.
对金属离子运输蛋白抑制和免疫细胞死亡 (ICD) 诱导的分析.

主要成果:

通过ZCA-LDH@DSF,Zn²⁺/Cu²⁺和DSF的pH响应释放得到启用.
2+和DSF形成有毒的CuET,诱导DNA损伤和亡.
细胞内Cu²⁺过载通过破坏TCA循环触发了cuproptosis.
Zn2+ 抑制了铜运输蛋白,增强了铜和诱导了烧.
协同细胞死亡途径显著增强了ICD,抑制了瘤生长和转移.

结论:

ZCA-LDH@DSF是一个有效的MIIT发起者,可以共同提供多种金属离子和药物.
复合物触发了多个细胞死亡程序,包括亡,亡和热亡.
这种方法增强了ICD,并证明了癌症治疗具有良好的生物安全性的重大潜力.

关键词:

这种疾病叫做cuproptosis.一个LDH纳米启动器.金属离子干扰疗法是一种金属离子干扰疗法.多金属离子的交叉电流是多金属离子的交叉电流.热性灭症 (Pyroptosis) 是一种

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