产前对金属和微量元素的个人和混合暴露以及学龄前儿童的内化和外化症状:前性出生队列研究
Yanyan Jiang1, Yingying Zuo1, Cong Geng1
1Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei, Anhui 230032, China.
Ecotoxicology and environmental safety
|December 9, 2025
概括
产前暴露于,和与增加儿童行为问题有关,而可能提供保护. 与的相关性显示出性别特异性差异,需要进一步调查.
科学领域:
- 环境健康 环境健康
- 发展心理学 发展心理学
- 毒理学 毒理学 毒理学
背景情况:
- 关于有毒金属对儿童行为的影响,存在不一致的发现.
- 元素混合物对儿童行为发展的影响尚不清楚.
研究的目的:
- 调查产前接触特定金属和微量元素与儿童行为发展之间的关联.
- 探索,,,,,,和的单个和混合作用.
- 检查这些协会中潜在的性别差异.
主要方法:
- 来自2514个母婴二合体的母体血清和带血样本被分析了三个月的金属度.
- 用1.5-5岁的儿童行为检查清单来评估行为发展.
- 采用了统计模型,包括通用线性模型,贝叶斯内核机器回归和量子g计算.
主要成果:
- 第二个三个月的母亲 (Cd), (Tl) 和 (Mo) 与内化,外化和总行为问题有积极的联系.
- (Se) 与行为问题得分有负面关联.
- 在男孩中,CD的影响更为明显,带血金属混合物暴露与总体问题较少有关.
结论:
- 产前暴露于Cd,Tl和Mo与更高的儿童行为问题的风险相关,具有显著的性别特异性变化.
- 可能会对儿童的行为问题产生保护作用.
- 需要进一步的研究来证实这些发现,并阐明性别差异背后的机制.
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