在尿液分泌期间,芳香微塑料碎片的潜在风险
Yoojin Lee1, Sung-Eun Heo1, Kyungtae Park1
1Department of Chemical & Biomolecular Engineering, College of Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
Journal of hazardous materials
|December 9, 2025
概括
微塑料的化学成分,而不仅仅是存在,决定了毒性. 像PET这样的芳香微塑料结合更多的蛋白质,在短暂的穿越身体过程中比聚烯 (PP) 造成更大的细胞损伤.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 材料科学 材料科学 材料科学
背景情况:
- 微塑料 (MP) 是无处不在的环境污染物.
- 它们在人体中的短暂存在通常被认为是无害的.
- 要了解MP的命运和毒性,需要考虑它们的各种物理化学性质.
研究的目的:
- 研究微塑料化学如何影响生物相互作用和毒性.
- 在人类血液模型中比较聚烯 (PP) 和芳香聚乙烯四甲 (PET) MPs 的作用.
- 为了阐明微塑料诱导的细胞应激沿循环到排泄轴的途径.
主要方法:
- 人类血液暴露于模仿生物圈的PP和PET微塑料碎片.
- 对蛋白质冠状形成和红细胞吸附的分析.
- 对微塑料粘附于内皮细胞和上皮细胞的评估.
- 测量细胞内活性氧物种 (ROS) 和亡标志物.
主要成果:
- 聚乙烯二甲 (PET) 由于 π-π 相互作用而形成比聚烯 (PP) 更密集的蛋白质冠状.
- 与PP相比,PET表现出血清蛋白和红细胞的吸附量显著更高.
- 蛋白质涂层的PET优先粘附于内皮细胞和上皮细胞,诱导更高的ROS和亡.
- 观察到细胞类型特定的干扰,将血管损伤与尿路压力联系起来.
结论:
- 微塑料的物理化学特性决定了生物命运和毒性.
- 芳香微塑料,如PET,由于增强的蛋白质结合和细胞相互作用,造成更大的风险.
- 这些发现揭示了一个被忽视的风险途径,并强调需要现实的暴露模型来评估微塑料风险.
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