在更年期过渡期期间,家族性高胆固醇血清症女性的脂质变化
Gia V Da Roza1, Lubomira Cermakova1, Jeanine Roeters van Lennep2
1Centre for Heart Lung Innovation, Department of Medicine, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
家族性高胆固醇血症 (FH) 在绝经后的女性中显著影响脂质水平. 在这种过渡期间,密切监测和治疗低密度脂蛋白胆固醇 (LDL-C) 是管理心血管风险的关键.
科学领域:
- 心脏病学 心脏病学
- 遗传学 是一个遗传学.
- 内分泌学 在内分泌学.
背景情况:
- 家族性高胆固醇血症 (FH) 是一种普遍存在的遗传疾病,每311个人中就有1人患上这种疾病,其特点是胆固醇水平高.
- 女性的脂质样本在绝经期间发生变化,但对FH患者的具体影响仍未得到充分研究.
研究的目的:
- 为了研究更年期过渡前和之后的FH女性的脂质水平和降脂疗法 (LLT) 的变化.
- 评估更年期对女性低密度脂蛋白胆固醇 (LDL-C) 和其他脂质的影响.
主要方法:
- 来自不列颠哥伦比亚省FH登记处的被诊断患有FH的女性患者的分析 (荷兰脂质临床网络得分≥6).
- 脂质谱和LLT在更年期前后使用情况的比较 (自我报告或在51岁时估计).
主要成果:
- 在FH女性中,LDL-C水平在绝经后增加了12% (0.78 mmol/L).
- 未经治疗的FH女性在绝经后的LDL-C (1.05 mmol/L) 增加了17%.
- 在更年期期间观察到总胆固醇,甘油三,非HDL-C和LLT使用的显著增加.
结论:
- 更年期过渡显著提高了LDL-C水平在女性的FH,增加了更年期后的心血管风险.
- 在更年期过渡期间,对患有FH的女性来说,密切监测和及时干预脂质管理至关重要.
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