增强透性和保留 (EPR) 效应:纳米医学的进步改善了瘤向的效果
Mohammad Sameer Khan1, Taha Alqahtani2, Humood Al Shmrany3
1Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India.
Biomaterials advances
|December 9, 2025
概括
在固体瘤中增强透性和保留效应 (EPR) 的策略对于纳米药物癌症治疗至关重要. 本综述探讨了改善纳米粒子输送和克服临床不一致性以获得更好的患者结果的方法.
科学领域:
- 在瘤学瘤学.
- 纳米医学是一种纳米医学.
- 生物医学工程 生物医学工程
背景情况:
- 增强的透性和保留 (EPR) 效应是纳米粒子在固体瘤中的积累的关键.
- 纳米医学的临床疗效受到EPR效应异质性和瘤微环境障碍的限制.
研究的目的:
- 为扩大EPR效应的策略提供一个转化视角,以改善纳米药物交付.
- 突出新兴途径,以提高基于EPR的疗法的临床可预测性.
主要方法:
- 对EPR效应调节策略的现有文献的审查.
- 分析方法包括血管正常化,血流调节和主动准.
- 探索瘤微环境的重塑和图像引导的交付.
主要成果:
- 通过EPR介导的纳米粒子输送的临床前成功与临床不一致性形成鲜明对比.
- 瘤的血管密度,间歇压力和肌肉壁垒阻碍了药物透.
- 多种策略显示出放大EPR效应的希望.
结论:
- 重新设计基于EPR的输送系统对于一致和强大的纳米医学至关重要.
- 整合机械见解与治疗创新可以导致针对固体瘤的个性化纳米医学.
- 未来的方向包括患者特定的诊断和先进的输送系统.
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