一个失调的肝素-铁轴会损害抗病毒免疫力,并诱导新生儿致命的肝病理

Yanhui Xu1, Xixi Chen2, Rongli Fang2

  • 1Department of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Clinical Research Center for Pediatric Infection and Immunity, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China.

Immunity
|December 9, 2025
PubMed
概括

新生儿的罗塔病毒感染会通过破坏I型干扰素 (IFN-I) 和肝素的铁调节而导致肝损伤. 叶酸补充剂在减少胆道缩的婴儿肝损伤和并发症方面表现有前途.

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