在腹部手术后治疗中度至重度急性疼痛的泰吉利利丁:一项随机,双盲,第三期临床试验
Tingting Wang1, Yafeng Wang1, Haihui Xie2
1Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, Wuhan, China.
Cell reports. Medicine
|December 9, 2025
概括
泰吉利利丁是一种新型偏向的μ-阿片类受体激动剂,有效地管理术后疼痛. 这项研究表明,泰吉利利丁的止痛效果优于安慰剂,与吗啡相当,副作用可能更少.
科学领域:
- 药理学 药理学是指药理学的学科.
- 麻醉学 麻醉学
- 疼痛管理 疼痛管理
背景情况:
- 泰吉利利丁是一种偏向的μ-阿片类受体激活剂,向G蛋白通路.
- 它旨在提供有效的止痛,降低阿片类药物相关副作用的发生率.
研究的目的:
- 评估tegileridine在经过腹部手术后经历术后疼痛的患者的疗效和安全性.
主要方法:
- 一个第三阶段的随机研究,涉及526名患者.
- 患者接受了安慰剂,泰吉利利里丁 (0.75毫克或1.0毫克) 或吗啡.
- 主要结局:总结24小时内休息时疼痛强度的差异 (SPID24).
主要成果:
- 与安慰剂相比,特吉利利利丁 (0.75毫克和1.0毫克) 的SPID24得分明显高于安慰剂 (p < 0.001).
- 24小时后的总疼痛缓解得分在泰吉利利丁和吗啡组之间是可比的.
- 泰吉利利丁在治疗术后疼痛方面表现出与吗啡相当的疗效.
结论:
- 泰吉利利丁是腹部手术后术后疼痛的有效止痛药.
- 它的疗效明显大于安慰剂,与吗啡相当.
- 泰吉利利利丁 (Tegileridine) 是一种有希望的疼痛管理选择,具有潜在的安全性.
相关概念视频
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy
519
Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
519
Analgesia and Pain Management
1.4K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
1.4K


