高血糖变异性作为一种风险因素,导致2型糖尿病中慢性病的进展,患有轻度至中度功能障碍
Taro Saigusa1, Kentaro Watanabe1, Masahiro Takubo1
1Division of Diabetes and Metabolic Diseases, Department of Internal Medicine, Nihon University School of Medicine, Itabashi, Japan.
概括
较大的HbA1c变异性增加了慢性病 (CKD) 在2型糖尿病患者中轻度功能障碍的进展风险. 仔细的血糖控制对于保持功能至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 内分泌学 在内分泌学.
- 糖尿病研究 糖尿病研究
背景情况:
- 2型糖尿病是慢性病 (CKD) 的主要原因之一.
- 估计的淋巴膜过率 (eGFR) 轻度至中度降低需要进一步调查关于CKD进展风险.
- 血糖控制的变化是糖尿病病的潜在,未被研究的因素.
研究的目的:
- 评估2型糖尿病患者与轻度至中度功能障碍患者的血糖控制变化和CKD进展之间的关联.
- 在这个特定的患者队列中确定CKD进展的预测因子.
主要方法:
- 追溯队列研究包括66名2型糖尿病患者和45-60毫升/分钟/1.73米2之间的eGFR.
- 8年的随访期,每年测量HbA1c和eGFR.
- 分析eGFR斜率,HbA1c波动 (变化系数) 和临床参数.
主要成果:
- 与EGFR下降患者相比,稳定的eGFR患者的HbA1c波动和变化系数 (CV) 显着更高 (P=0.011).
- 年龄较大也与eGFR下降有关 (P=0.049).
- 一个标准偏差增加的CV显著与eGFR下降相关 (OR,1.99;P=0.041).
结论:
- 血糖变异性增加,由较高的HbA1c波动和CV表明,与患有轻度至中度功能障碍的2型糖尿病患者中CKD进展的风险增加有关.
- 保持稳定的血糖控制可能对减缓糖尿病患者慢性病进展至关重要.
- 需要进一步的前性研究来证实这些发现并探索干预策略.
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