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用氨酸涂层的ZIF-8纳米颗粒用于在类风湿性关节炎中增强和控制的甲状腺素递送

Reyhane Masoudifar¹, Golrokh Farnam², Niki Pouyanfar¹

¹Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

International journal of pharmaceutics

|December 9, 2025

概括

覆盖着氨酸的纳米颗粒有效地提供甲状腺素治疗类风湿性关节炎. 这种有针对性的方法增强了药物在炎症组织中的积累,提高了疗效,减少了副作用.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
类风湿病学类风湿病学

背景情况:

甲甲酸 (MTX) 对于类风湿性关节炎 (RA) 是至关重要的,但它有副作用和生物可用性差.
需要有针对性的药物输送系统来提高MTX的疗效,并减少RA患者的毒性.

研究的目的:

开发氨酸 (HA) 涂层的ZIF-8纳米颗粒 (NP) 用于针对性地在RA中提供MTX.
评估封装效率,药物释放特征和开发的NP的细胞吸收.

主要方法:

使用现场方法将MTX封装到ZIF-8NP中,然后再涂上HA涂层.
量化了药物负载 (EE%和LC%).
实验室药物释放研究在pH值7.4和5.6.6进行.
细胞毒性和细胞吸收测定是在RAW 264.7巨细胞上进行的.

主要成果:

覆盖HA的ZIF-8NP实现了68.96%的捕获效率和30.88%的负载能力.
纳米粒子表现出pH响应,持续的药物释放,在酸性pH (5.6) 时完全释放MTX.
增强的生物相容性和巨细胞的向细胞吸收被证实为HA涂层NP.

结论:

用HA涂层的ZIF-8NP显示出作为RA治疗中MTX的向药物输送平台的巨大潜力.
这种策略可以通过增加炎症部位的药物积累和最大限度地减少全身毒性来改善治疗结果.

关键词:

药物输送是药物输送的过程.氨酸涂层是一种氨酸涂层.甲基甲酸二醇的使用方法类风湿性关节炎类风湿性关节炎类风湿性关节炎这是一种ZIF-8纳米粒子.药物释放反应于pH的药物释放.

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