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降低ALPS指数和肺气以及COPD患者的认知功能之间的关联

Xinying Lian¹, Can Li², Jingchun He³

¹The Fourth Central Clinical School, Tianjin Medical University, Tianjin, 300140, China; Department of Radiology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, 300121, China.

Respiratory medicine

|December 9, 2025

概括

患有慢性阻塞性肺病 (COPD) 的患者表现出沿周血管空间 (ALPS) 指数的扩散率较低. 这一指数与COPD患者的认知能力下降,肺气的严重程度和疾病持续时间相关.

科学领域:

神经成像是一种神经成像.
肺部医学肺部医学
放射学放射学是一门学科.

背景情况:

慢性阻塞性肺病 (COPD) 与系统性并发症有关.
在周脉空间 (DTI-ALPS) 沿线的扩散张力成像测量大脑微观结构.
在COPD中调查DTI-ALPS可能会揭示潜在的神经病理学.

研究的目的:

为了评估与健康对照组相比,COPD患者的ALPS指数.
评估ALPS指数与COPD临床特征,认知功能和肺重度之间的相关性.

主要方法:

前性研究包括41名COPD患者和38名健康志愿者.
进行了磁共振成像 (MRI) 和计算机断层扫描 (CT) 扫描.
从DTI数据计算的ALPS指数;从CT图像中LAA%_-950;评估认知功能.

主要成果:

在COPD患者中,ALPS指数明显较低 (P = 0.003).
ALPS指数与迷你精神状态检查得分 (r = 0.445,P = 0.004),疾病持续时间 (r = -0.555,P < 0.001) 和LAA%_-950 (r = -0.356,P = 0.042) 相相关.
经过调整以考虑混因素后,这些相关性仍然显著.

结论:

慢性肺炎患者的ALPS指数降低,表明大脑周血管空间发生了变化.
ALPS指数与COPD的认知障碍,肺气和疾病持续时间有关.
研究结果表明,DTI-ALPS可能为COPD相关的脑损伤机制提供了洞察力.

关键词:

慢性阻塞性肺病是一种慢性阻塞性肺病.扩散张力成像的成像方法淋巴系统淋巴系统磁共振成像技术磁共振成像技术多切片计算机断层扫描 (Multislice computed tomography) 是一种计算机断层扫描.

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