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相关概念视频

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

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Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
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Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

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Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
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Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

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Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
135
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

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In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
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Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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儿科口服分解片:从多个方面看待未来

Zixi Yin1, Xiao Lin1, Yanlong Hong2

  • 1School of Pharmacy, Shanghai University of Traditional Chinese Medicine, No. 1200, Cai-Lun Road, Pudong District, Shanghai 201203, PR China; Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine of Ministry of Education, Shanghai University of Traditional Chinese Medicine, No. 1200, Cai-Lun Road, Pudong District, Shanghai 201203, PR China.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
|December 9, 2025
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概括

口服分解片 (ODT) 提供了改善的儿科药物遵守. 本综述分析了ODT的制造,质量控制和儿童的未来应用,解决药物短缺问题.

关键词:
辅助物质 辅助物质 辅助物质制造 制造 制造 制造口服可分解片,可消化片儿科 儿科 儿科质量控制 质量控制

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科学领域:

  • 制药技术 制药技术 制药技术
  • 儿科药物输送 儿科药物输送
  • 配方科学科学 配方科学

背景情况:

  • 口服分解片 (ODT) 越来越受欢迎,原因是易于服用和快速作用.
  • 专门用于儿科的药物面临着全球短缺和有限的市场规模,影响治疗机会.
  • ODT为提高药物服药性和扩大儿科患者覆盖率提供了重要机会.

研究的目的:

  • 审查制造技术,辅助剂和质量控制挑战,特别是儿科ODT.
  • 探索儿科ODT的未来发展趋势和潜在应用.
  • 通过分析独特的儿科患者方面,为儿科ODT的发展提供参考.

主要方法:

  • 对ODT制造和儿科方面的现有文献进行分析.
  • 对儿科ODT开发中的质量控制策略和挑战的审查.
  • 基于设计质量 (QbD) 原则,对未来的趋势,应用和挑战进行前性分析.

主要成果:

  • 由于患者独特的因素,儿科ODT需要量身定制的制造和质量控制方法.
  • 优化质量控制涉及研究,制造,市场和临床实践的持续循环.
  • 未来的应用预计在急性疾病,精神障碍,口腔健康和儿科呼吸系统疾病中得到应用.

结论:

  • 在改善儿科药物服药性和解决药物可及性问题方面,ODT具有很大的前景.
  • 设计质量 (QbD) 框架和个性化医学趋势将推动儿科ODT质量优化.
  • 进一步研究和开发儿科ODT对于扩大儿童治疗选择至关重要.