处方阿片类药物的使用和身体不活动:独立的关联,没有与睡眠障碍的多重相互作用
Chaomin Wu1, Gongchen Duan1, Faxing Wang1
1Department of Anesthesiology, Lishui People's Hospital, The First Affiliated Hospital of Lishui University, Wenzhou Medical University Lishui Hospital, China.
Journal of affective disorders
|December 9, 2025
概括
处方阿片类药物的使用和体力活动 (PA) 独立地与睡眠障碍的可能性增加有关. 促进PA可能会改善睡眠健康,即使对于那些服用阿片类药物的人来说也是如此.
科学领域:
- 睡眠医学 睡眠医学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 睡眠障碍影响全球大约三分之一的成年人群.
- 处方阿片类药物的消费和体力活动 (PA) 都是睡眠健康的潜在调节者.
研究的目的:
- 调查处方阿片类药物使用和体力活动水平与自我报告的临床医生诊断的睡眠障碍的几率的独立和联合关联.
- 探索不同类型的身体活动和睡眠障碍患病率之间的剂量反应关系.
主要方法:
- 分析了国家健康和营养检查调查 (NHANES) 的四个周期 (2007-2014) 的汇总数据.
- 调查加权后勤回归模型被用于估计睡眠障碍的几率比率 (OR) 和95%置信区间 (CI),调整为各种共同变量.
- 限制立方线 (RCS) 用于检查身体活动的剂量反应模式,并进行敏感性分析,包括对抑郁症和镇静剂/催眠药的使用进行调整.
主要成果:
- 处方阿片类药物的使用与睡眠障碍的更高几率显著相关 (OR 1.82;P < 0.001).
- 较高水平的体力活动 (PA) 也与睡眠障碍的可能性增加有关 (OR 1.33; P = 0.002).
- 使用阿片类药物和从事不活动的人患睡眠障碍的几率最高 (OR2.04),与没有使用阿片类药物和活跃PA的人相比.
结论:
- 处方阿片类药物的使用和身体不活动都与睡眠障碍的风险增加有关.
- 鼓励适度参与交通和休时间的体育活动可能会为睡眠健康带来好处,可能包括使用处方阿片类药物的个人.
- 进一步的纵向研究是有必要的,以确定因果关系,并了解剂量-持续时间影响.
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