状态过渡动态的改变及其在精神分裂症和双相情感障碍中的临床意义
Langhua Shi1, Haifang Li2, Meirong Song1
1College of Computer Science and Technology (College of Data Science), Taiyuan University of Technology, Taiyuan, 030024, Shanxi, China.
Journal of affective disorders
|December 9, 2025
概括
精神分裂症和双相情感障碍患者表现出改变的大脑状态过渡,由新指标异态过渡能量 (HeTE) 和同态维护能量 (HoME) 表示. 这些措施对诊断和预测这些情况的症状严重程度有希望.
科学领域:
- 神经科学是一个神经科学.
- 精神疾病 精神疾病
- 计算精神病学是一种计算精神病学.
背景情况:
- 精神分裂症 (SZ) 和双相情感障碍 (BD) 是与认知障碍相关的严重精神疾病.
- 人们认为认知功能依赖于不同大脑状态之间的动态过渡.
- 在SZ和BD患者中,这些状态过渡中的异常尚未得到充分理解.
研究的目的:
- 调查SZ和BD患者大脑状态转换动态的变化.
- 探索这些动态和症状严重程度之间的关系.
- 引入用于量化状态过渡属性的新型指标.
主要方法:
- 提出了两个新的状态过渡指标:异态过渡能量 (HeTE) 和同态维护能量 (HoME),整合结构和功能大脑信息.
- 将HeTE和HoME与传统可控制性指标 (平均和模式可控制性) 进行比较.
- 进行了跨组比较,相关性分析,参与者分类和临床规模预测.
主要成果:
- 与对照组相比,SZ和BD患者的HeTE显著增加,HoME显著减少.
- 无论是HeTE还是HoME,都与节点程度负相关.
- HeTE和HoME的组合在分类SZ患者和可靠预测临床尺度 (BPRS,SANS) 中取得了高准确性 (97.76%).
结论:
- 在SZ和BD中HeTE和HoME的异常表明状态过渡效率受损,并倾向于维持病态状态,可能导致认知不灵活性.
- 拟议的HeTE和HoME指标比传统的可控制性指标更为敏感.
- 在精神疾病中,HeTE和HoME可以作为指导功能恢复的有价值的定量标记.
相关概念视频
Bipolar Disorder
602
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
602
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
1.8K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
1.8K
Mania and Antimanic Drugs: Overview
530
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
530
Positive Symptoms of Schizophrenia: Hallucinations and Delusions
510
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
510
Psychological and Sociocultural Causes of Schizophrenia
450
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
450
Biological Causes of Schizophrenia
467
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
467


