一个可穿戴的多式纳米跟踪器,用于非侵入性,同时进行药理动力学和药理动力学监测
Ziyu Zhu1, Wei Deng1, Long Zheng1
1Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education, State Key Laboratory of Integrated Optoelectronics, Key Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Analysis and Testing Center, Department of Chemistry, Northeast Normal University, Changchun, Jilin Province 130024, China.
ACS sensors
|December 9, 2025
概括
这项研究引入了一种可穿戴式传感器,用于实时监测药物反应. 该P2NanoTrek设备跟踪药物水平和生理效应,推进个性化医疗.
科学领域:
- 生物医学工程 生物医学工程
- 药理学 药理学是指药理学的学科.
- 可穿戴技术可穿戴技术
背景情况:
- 个体生理变异性需要实时监测药物相互作用的精密医学.
- 目前用于同时进行药理动力学 (PK) 和药理动力学 (PD) 监测的非侵入性方法有限,并且在技术上具有挑战性.
- 开发可穿戴传感器用于个性化药物反应跟踪对于日常医疗保健和太空探索等专业环境至关重要.
研究的目的:
- 开发和验证一个集成的多式联网可穿戴传感器,NanoTracker (P2NanoTrek),用于非侵入性,实时监测PK和PD生物标志物.
- 评估传感器在跟踪人类参与者中甲醇 (一种PK生物标志物) 和心率 (一种PD生物标志物) 的能力.
- 通过关联汗水和血药物水平并分析生理反应来证明P2NanoTrek在个性化药物治疗中的潜力.
主要方法:
- 开发一个集成的多模式可穿戴传感器 (P2NanoTrek),用于皮肤上的非侵入性监测.
- 实时测量汗水甲醇 (PK) 和心率 (PD) 在人类参与者在甲醇的管理后.
- 汗水和血中甲醇度的相关性,以及在标准化剂量方案中评估心率变化.
主要成果:
- P2NanoTrek成功启用了实时,非侵入性监测汗水甲醇和心率.
- 测量是在与药物吸收和排泄相关的条件下进行的.
- 该研究表明,汗水和血中甲醇水平之间存在相关性,支持其对个性化治疗的潜力.
结论:
- P2NanoTrek系统为实时,非侵入性监测药物PK和PD反应提供了一种新的方法.
- 这项技术对推进个性化药物治疗和精准医学具有重大前景.
- 可穿戴式传感器可在不同的环境中对治疗药物效果进行个性化跟踪.
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