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在原发性乳腺癌中三级淋巴状结构的预后价值及其与免疫微环境的关联

YunXia Xu¹, ShuiLong Liu¹, XiaoKai Ling¹

¹Breast and Thyroid Surgery, Hangzhou Linping District Maternal & Child Health Care Hospital, Hangzhou, China.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

|December 9, 2025

概括

乳腺癌 (BC) 中的三级淋巴体结构 (TLS) 与更好的结果有关. 它们的存在,特别是成熟的TLS,与改善无复发生存率和增加CD4+T细胞透率相关,这表明它们在免疫反应中起作用.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
病理学病理学病理学

背景情况:

三级淋巴体结构 (TLS) 是各种疾病中发现的短暂免疫聚合物.
它们在原发性乳腺癌 (BC) 中的作用和与瘤免疫微环境的关联仍然不完全理解.

研究的目的:

研究TLS在原发性乳腺癌中的分布,成熟度和预后意义.
分析TLS特征与瘤免疫微环境之间的关系,包括免疫细胞透和患者存活率.

主要方法:

对60个原发性乳腺癌瘤样本的回顾性分析.
免疫组织化学染色以评估TLS的存在和成熟度.
卡普兰-梅尔生存分析和后勤回归来评估无复发生存率 (RFS) 和预测因素.

主要成果:

在58.33%的患者中检测到TLS,二次卵泡状TLS是最常见的成熟类型.
TLS的存在与更高的雌激素和孕激素受体表达相关 (p<0.05).
TLS的存在与改善的RFS (HR=0.163,p=0.035) 和增加的CD4+T细胞透 (p=0.004) 有显著的相关性.

结论:

成熟的TLS,特别是二次毛囊状结构,与有利的临床病理特征和改善原发性乳腺癌的预后有关.
TLS的存在表明增强了CD4+T细胞的透,突出了它们在调节瘤免疫微环境中的作用.
TLS可以作为预后生物标志物和乳腺癌免疫调节疗法的潜在目标.

关键词:

免疫组织化学免疫组织化学成熟成熟成熟成熟.原发性乳腺癌是什么意思三级淋巴体结构的第三级淋巴体结构瘤微环境是一个微环境.

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