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[⁶⁸Ga]Ga-FAPI 与[¹⁸F]FDG PET/CT 在带有塑性线膜炎的标记环细胞癌中:诊断性能和陷

Roopal Agrawal¹, Keerti Sitani¹, Sandip Basu²

¹Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Centre, Mumbai, India; and Homi Bhabha National Institute, Mumbai, India.

Journal of nuclear medicine technology

|December 9, 2025

概括

诊断晚期胃癌,尤其是塑性线炎,是很困难的. 纤维细胞激活蛋白抑制剂成像显示在这些情况下高瘤吸收,超过标准的FDG PET/CT扫描.

科学领域:

在瘤学瘤学.
放射学放射学是一门学科.
分子成像学分子成像学

背景情况:

胃癌,特别是塑性线炎,存在诊断方面的挑战.
纤维细胞激活蛋白 (FAP) 在与癌症相关的纤维细胞中高度表达,为向成像提供了潜力.
像[18F]FDG PET/CT这样的标准成像在某些胃癌亚型中可能显示出有限的效用.

研究的目的:

为了评估纤维细胞激活蛋白抑制剂 ([68Ga]Ga-FAPI-04) PET/CT在带有塑性线性炎形态的封号环细胞胃腺癌的诊断性能.
在这些具有挑战性的案例中,将[68Ga]Ga-FAPI-04 PET/CT发现与[18F]FDG PET/CT进行比较.

主要方法:

2名患有封戒细胞胃腺癌和塑性线炎的患者的病例报告.
使用[68Ga]Ga-FAPI-04 PET/CT和[18F]FDG PET/CT进行成像.
评估瘤吸收和瘤与背景对比度.

主要成果:

这两种情况都显示[18F]FDG PET/CT的吸收量很小.
在这两种情况下都观察到[68Ga]Ga-FAPI-04 PET/CT的强烈吸收.
纤维细胞激活蛋白抑制剂成像显示了高瘤与背景对比度.

结论:

[68Ga]Ga-FAPI-04 PET/CT与[18F]FDG PET/CT相比,在线性塑性胃癌的诊断性能优越.
纤维细胞激活蛋白抑制剂成像是挑战胃癌诊断的一个有希望的工具.
向纤维细胞激活蛋白可以改善特定胃癌亚型的可视化.

关键词:

[18F]FDG PET/CT PET/CT PET/CT [18F]FDG PET/CT PET/CT/CT [18F]FDG PET/CT PET/CT/CT [18F]FDG PET/CT/CT [68Ga]Ga-FAPI PET/CT 是一个可靠的材料.胃腺癌胃腺癌胃腺癌封印戒指细胞癌瘤是什么?

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