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Updated: Sep 8, 2026

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小细胞肺癌:免疫冷瘤的解剖学

David Millrine1, Kathryn L Simpson2, Fiona Blackhall3

  • 1Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, UK; Cancer Research UK Lung Cancer Centre of Excellence at the University of Manchester, Manchester, UK.

Trends in cancer
|December 9, 2025
PubMed
概括

小细胞肺癌 (SCLC) 是一种侵袭性瘤. 最近的基因组研究揭示了SCLC中多样化的免疫格局和细胞可塑性,为了解为什么免疫检查点抑制剂 (ICI) 仅对少数患者有益,提供了新的见解.

关键词:
在SCLC中,SCLC是最重要的.癌症 炎症 癌症 炎症免疫疗法 免疫疗法

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相关概念视频

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...