克罗恩病患者的非酒精性脂肪肝疾病:活跃和不活跃阶段的差异
Minzhi Lin1, Na Diao1, Huili Guo1
1Department of Gastroenterology, the Sixth Affiliated Hospital, Sun Yat-sen University, China; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, the Sixth Affiliated Hospital, Sun Yat-sen University, China.
大约20%的克罗恩氏病 (CD) 患者会发展非酒精性脂肪性肝病 (NAFLD),主要是瘦性NAFLD. 不同的CD活性水平呈现出不同的NAFLD风险因素和特征,大多数病例在CD治疗后得到改善.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 内部医学 内部医学
背景情况:
- 克罗恩病 (CD) 活动是非酒精性脂肪肝疾病 (NAFLD) 的已知危险因素.
- 关于不同CD活动水平的NAFLD患病率和特征的研究有限.
- 这项研究调查了在患有活性与非活性CD的患者中NAFLD.
研究的目的:
- 为了确定克罗恩病患者中NAFLD的患病率.
- 为了确定与NAFLD相关的风险因素,在活跃和不活跃的CD.
- 分析CD治疗后NAFLD的预后.
主要方法:
- 在2014-2017年间诊断的844名连续CD患者的回顾性分析.
- 将患者分为活跃和不活跃的CD组.
- 评估临床特征,风险因素和治疗后的NAFLD结果.
主要成果:
- 在CD患者中,NAFLD的患病率为20.38%,主要是瘦体NAFLD (80.23%).
- 活跃CD (23.1%) 的NAFLD和瘦体NAFLD比不活跃CD (15.9%) 更常见.
- 风险因素包括较高的BMI,C反应蛋白和较低的白蛋白;具体因素因CD活性而异.
结论:
- NAFLD影响大约五分之一的CD患者,通常是瘦体NAFLD.
- 活跃与非活跃CD中NAFLD的不同风险因素和特征表明不同的潜在机制.
- 在大多数受影响的患者中,CD治疗有效地减轻了NAFLD.
更多相关视频
07:03Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
Published on: July 19, 2024
04:14Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis NASH Resolution
Published on: April 16, 2019
相关概念视频
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Ultrasound II: Endoscopic Ultrasound and FibroScan
Endoscopic Ultrasound (EUS):
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
