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关于FAPI PET的非恶性发现:对文献进行最新的快速系统审查
Morten Bentestuen1, Sara Dahlsgaard-Wallenius2, Marie M K Stolberg3
1Department of Nuclear Medicine and Clinical Cancer Research Center, Aalborg University Hospital, Denmark; Department of Clinical Medicine, Aalborg University, Denmark.
Seminars in nuclear medicine
|December 9, 2025
概括
纤维细胞激活蛋白抑制剂 (FAPI) PET扫描显示在非恶性疾病中吸收,影响癌症诊断. 本综述详细介绍了这些发现以及FAPI PET成像的新指示.
科学领域:
- 核医学是一种核医学.
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 纤维细胞激活蛋白抑制剂 (FAPI) PET成像显示在瘤学中具有显著的诊断效用.
- 之前的审查强调了非恶性疾病中的FAPI吸收,需要更新分析.
- 了解非恶性FAPI PET发现对于准确的癌症诊断和识别新应用至关重要.
研究的目的:
- 系统地审查和总结FAPI PET扫描中非恶性发现的当前证据.
- 为了确定FAPI PET在癌症诊断中的常见陷,由于非恶性吸收.
- 在非恶性疾病中探索FAPI PET的新兴指示.
主要方法:
- 在PubMed,Embase和Web of Science进行了系统的文献搜索,截至2025年5月2日.
- 包括使用FAPI追踪剂对人类受试者的同行评审研究,重点关注2022年4月至2025年5月之间的发现.
- 来自380项报告了8230个非恶性FAPI PET发现的研究数据被按解剖区域分析.
主要成果:
- 大多数研究来源于中国 (70%),病例报告比例很高 (63%).
- 虽然许多扫描最初是用于癌症评估 (69%),但非恶性征兆正在增加.
- 常见的陷包括在感染,炎症,纤维化和良性瘤中吸收FAPI;新出现的迹象包括间歇性肺病,心脏病和关节炎.
结论:
- 本综述提供了非恶性FAPI PET发现的全面摘要.
- 它作为解释FAPI PET扫描在诊断和研究环境中的关键参考.
- 准确解释非恶性FAPI吸收对于推进FAPI PET应用至关重要.
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