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基线主动脉炎对GCA主动脉扩张风险的影响:一个多中心成像研究

Chiara Marvisi^1,2, Konstanze V Guggenberger³, Giulia Besutti^4,5

¹Rheumatology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy.

Rheumatology (Oxford, England)

|December 9, 2025

概括

在诊断时,大动脉干扰在巨细胞动脉炎 (GCA) 中很常见. 基线大动脉直径是GCA患者未来大动脉扩张的关键预测指标,需要早期成像和监测.

科学领域:

心血管医学心血管医学
类风湿病学类风湿病学
放射学放射学是一门学科.

背景情况:

巨细胞动脉炎 (GCA) 是一种全身性血管炎,可以影响大动脉,特别是大动脉.
主动脉并发症,包括主动脉炎和扩张,已被认可,但其在新诊断的GCA中的患病率和进展尚未完全描述.

研究的目的:

在GCA诊断时确定主动脉炎和主动脉扩张的频率.
估计大动脉直径随着时间的推移而增加的速度.
确定预测GCA患者新动脉扩张发展的因素.

主要方法:

来自两个欧洲中心的157名新发性GCA患者的回顾性队列研究.
基线和随访胸前大动脉成像分别在诊断后6个月内和≥6个月内进行.
使用多变量回归分析基线大动脉直径,大动脉膨胀率 (cm2/年) 和事件大动脉扩张.

主要成果:

在60.4%的患者中存在大动脉炎;19.6%的患者有起始水平的大动脉扩张,主要在上升大动脉中部.
大动脉炎与较大的大动脉直径相关,并且增加了基线扩张的几率 (ORadj=2.3).
在平均30个月的随访期间,9.8%的患者出现了发生性大动脉扩张. 基线大动脉直径是扩张 (β=0.088) 和新扩张 (HRadj=3.9) 的最强预测因素.

结论:

大动脉异常在GCA诊断时很常见.
基线大动脉直径是GCA中随后的大动脉扩张的最重要的预测指标.
早期胸部成像和持续监测大动脉尺寸对于管理GCA患者至关重要.

关键词:

动脉瘤是一个动脉瘤.在FDG PET/CT中使用.巨细胞动脉炎的发生大血管血管血管炎这是一个MRA MRA.

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