在用特拉洛金纽马布治疗亚托皮性皮炎的抗IL-13疗法下,出现牛皮形关节炎的发展
Katya Meridor1,2,3, Sook Yan Lee4, Ilona Blee5
1NIHR Leeds Biomedical Research Centre, The Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Rheumatology (Oxford, England)
|December 9, 2025
概括
用特拉洛金纽马布抑制介质素-13 (IL-13) 可能会在一些阿托皮性皮炎患者中引发牛皮关节炎 (PsA) 类症状. 这些病例表明IL-13阻断可能在PsA发展中发挥作用.
科学领域:
- 免疫皮肤学 免疫皮肤学
- 类风湿病学 类风湿病学
- 临床免疫学 临床免疫学
背景情况:
- 皮炎 (AD) 中IL-4和IL-13的双重阻塞与IL-23/IL-17轴激活有关.
- 矛盾的是,这种轴的激活可能会诱导牛皮和牛皮关节炎 (PsA) 状况.
- 驱动这些反应的特定细胞因子需要澄清.
研究的目的:
- 调查抗IL-13疗法与类似PSA的表现之间的潜在联系.
- 报告一系列病例,患者在治疗阿尔茨海默症后出现了类似PSA的症状.
主要方法:
- 在开始治疗阿尔茨海默氏症后,确定了四名患有类似PSA的患者 (关节,内,皮肤).
- 评估临床特征,实验室发现,成像和治疗结果.
- 审查了139名在英国两个中心接受特拉洛金努马布治疗的患者.
主要成果:
- 在139名患者中,有4名患者在开始使用特拉洛金巴后出现了新发的类似PSA的炎症性关节炎和肠炎.
- 所有受影响的患者之前都失败了杜皮卢马布治疗.
- 皮肤活检和关节成像证实了类似PSA的特征;在停止或修改治疗后症状消失.
结论:
- 这是第一个将关节炎和肠炎与抗IL-13疗法 (tralokinumab) 联系起来的案例系列.
- 研究结果表明,在类似PSA的表现中,IL-13抑制的潜在病原遗传作用.
- 需要进一步的研究来探索这种关联.
相关概念视频
T Cell Types and Functions
2.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.1K
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
447
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
447
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
435
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
435
Inflammatory Bowel Disease II: Crohn's Disease
909
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
909
Autoimmune Disorders
1.4K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
1.4K


