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Updated: Jan 9, 2026

Light-driven Enzymatic Decarboxylation
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细胞染色体P450 RosC的酶工程为控制代氧化的因素提供了机械洞察力

Yohei Iizaka1, Hironori Suzuki2, Nanako Sasa2

  • 1Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba, Japan. yohei.iizaka@phar.toho-u.ac.jp.

Applied microbiology and biotechnology
|December 9, 2025
PubMed
概括

RosC酶的突变将其代氧化功能限制在单一步,损害基质结合并降低反应效率. 关键残留物Leu-176和Ser-248对于在多步氧化过程中定位基质至关重要.

关键词:
晶体结构 晶体结构细胞染色体P450酶的使用循序渐进的氧化过程宏化物生物合成多个阶段的催化剂.反应控制的反应控制.

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