化疗后乳腺癌的大脑功能和结构变化:系统性审查和元分析
Ying Chen1, Bin Wang2, Xu Wang3
1Acupuncture and Moxibustion Department, Beijing University of Chinese Medicine, Beijing, China.
Neuropsychology review
|December 9, 2025
概括
化疗可以改变乳腺癌患者的大脑结构和功能,特别是影响认知和情绪调节区域. 高等教育可能会对这些神经毒性影响提供一些保护.
科学领域:
- 神经科学是一个神经科学.
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 化疗是一种标准的乳腺癌治疗方法.
- 对中枢神经系统的神经毒性影响是已知的副作用.
- 了解这些影响对于患者护理至关重要.
研究的目的:
- 在乳腺癌患者中确定与化疗相关的一致的大脑结构和功能变化.
- 探索临床相关性,如年龄和教育.
- 调查潜在的保护因素.
主要方法:
- 对29项神经成像研究的基于坐标的元分析.
- 包括结构性MRI,扩散张力成像和静止状态fMRI.
- 将化疗治疗的患者与未接受化疗的对照进行比较.
主要成果:
- 在轨道前皮层,前带皮层,胰岛,小脑和Rolandic operculum中观察到显著的灰质减少.
- 功能性低活化发现在Rolandic部和insula.
- 高等教育水平可能会减轻神经毒性影响.
结论:
- 化疗主要影响涉及认知和情绪调节的大脑区域.
- 大脑的结构和功能变化与化疗治疗有关.
- 教育可能在预防化疗引起的神经毒性方面发挥保护作用.
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