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在激光 iridotomy 后的 phakic 眼睛中与 omidenepag isopropyl 相关的扩散双边斑点 edem:一个病例报告
Do Young Kim1,2, Ji Hyun Kim3
1Department of Ophthalmology, Yonsei University College of Medicine, Seoul, South Korea.
Japanese journal of ophthalmology
|December 9, 2025
概括
一种青光眼药物Omidenepag isopropyl可以引起扩散的双边斑点,甚至在光眼中. 这一案例强调了在使用这种前列腺素E受体2激动剂时需要谨慎,特别是在激光外周 iridotomy.
科学领域:
- 眼科医生 眼科 眼科
- 药理学 药理学是指药理学的学科.
背景情况:
- 奥米德内帕格异烯是一种选择性前列腺素E受体2激动剂,用于玻璃眼.
- 黄斑是已知的副作用,主要在伪眼中报告.
- 激光外周 iridotomy 是一个常见的程序,用于角关闭玻璃眼.
研究的目的:
- 报告一个发散双边斑点的病例在一个 phakic 患者使用omidenepag isopropyl.
- 为了突出在特定患者群体中对omidenepag isopropyl的潜在眼部副作用.
主要方法:
- 一个63岁的男性的病例报告,患有主要的闭角光眼.
- 患者之前曾经接受过激光外周性 iridotomy,并被规定为omidenepag isopropyl.
- 通过光学连贯断层扫描 (OCT) 证实了扩散性黄斑的诊断.
主要成果:
- 患者在使用omidenepag isopropyl4个月后出现视力模糊和扩散双边斑点.
- 停止使用omidenepag isopropyl和使用fenac 酸盐治疗导致水的消失.
- 在经过2个月的治疗后,OCT证实了黄斑的消失.
结论:
- 欧米德内帕格异酸可诱发发光眼双侧斑点,即使在激光外周 iridotomy.
- 斑点呈现为分散的视网膜加厚,与典型的囊形状不同.
- 建议谨慎使用omidenepag isopropyl,考虑到对OCT测量的潜在影响,如cpRNFL厚度.
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