内毒性ALK阳性形大细胞淋巴瘤
Eilena Braye1, Laurence de Leval2
1Promed Laboratoire SA, Department of Pathology, Marly, Switzerland.
Journal of hematopathology
|December 9, 2025
概括
具有独家内内浸透的无塑性大细胞淋巴瘤 (ALCL) 是罕见的. 这种呈现模仿转移性癌瘤,但需要迅速识别,以有效治疗ALK阳性ALCL.
科学领域:
- 血液病理学 血液病理学
- 在瘤学瘤学.
- 淋巴瘤研究 淋巴瘤研究
背景情况:
- 无塑性大细胞淋巴瘤 (ALCL),特别是ALK阳性亚型,可以涉及淋巴结鼻腔.
- 单独的ALCL对淋巴结的透是一种非常罕见的表现.
研究的目的:
- 描述一个独特的ALK阳性ALCL病例,该病例呈现出一个 inguinal淋巴结的单独的intrasinusoidal透.
- 为了强调这种罕见的模式所带来的诊断挑战,这种模式可以模仿转移性癌症.
- 强调认识到这种呈现对于适当管理的重要性.
主要方法:
- 一个39岁的妇女的病例报告,患有I阶段的 inguinal lymphadenopathy.
- 淋巴结组织病理学检查,包括对CD30和ALK的免疫组织化学检查.
- 临床相关性和诊断工作.
主要成果:
- 观察到CD30和ALK阳性非典型细胞的大规模透.
- 淋巴结架构被保留了,尽管有广泛的透.
- 这种模式模仿了转移性癌症,这给诊断带来了挑战.
结论:
- 单独的ALK阳性ALCL的透是淋巴腺病例中罕见但至关重要的差异诊断.
- 及时识别是必不可少的,因为ALK阳性ALCL通常对治疗反应良好.
- 需要进一步的研究来阐明这种特定表现的临床和预后意义.
相关概念视频
02:39lncRNA - Long Non-coding RNAs
9.7K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.7K
01:15Secondary Lymphoid Organs
8.7K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
8.7K