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Updated: Jun 10, 2026

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
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实施N-术语学和机器学习来探测Nt-arginylation

Shinyeong Ju1, Laxman Nawale2,3, Seonjeong Lee1

  • 1Chemical and Biological Integrative Research Center, Korea Institute of Science and Technology, Seoul, Republic of Korea.

Nature communications
|December 9, 2025
PubMed
概括

研究人员开发了一种新方法来检测N端 arginylation (Nt-arginylation),这是一个关键的蛋白质修饰涉及到细胞过程. 这种技术可以识别新的部位,有助于发现潜在的生物标志物和药物点.

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Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
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During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R stands for...