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释放有氧运动对MAFLD的益处:一个全面的机械分析分析

Wenting Zhang¹, Yu Hu², Fang Zou³

¹The Queen Mary School, Jiangxi Medical College, Nanchang University, 999 Xuefu Road, Nanchang, Jiangxi, 330031, China.

Journal of translational medicine

|December 9, 2025

概括

有氧运动通过调节脂质代谢和改善细胞应激反应来对抗与代谢功能障碍相关的脂肪肝疾病 (MAFLD). 本综述详细介绍了通过运动为MAFLD提供治疗益处的分子机制.

科学领域:

肝病学和代谢疾病
运动生理学运动生理学
分子生物学分子生物学

背景情况:

与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是一个日益严重的全球健康问题,其特点是脂肪在肝脏中积累.
目前对MAFLD的治疗方法缺乏向药物和长期干预措施.
有氧运动是一种公认的,可访问的策略,可以减缓MAFLD的进展,但其潜在机制需要系统的总结.

研究的目的:

系统地审查有氧运动改善代谢功能障碍相关脂肪肝疾病 (MAFLD) 的分子机制.
确定关键的分子标和信号通路,参与运动对MAFLD的治疗效果.
为开发有针对性的MAFLD干预提供理论基础.

主要方法:

整合最近的PubMed研究和已建立的实验模型 (例如,高脂肪饮食诱导的小鼠,HepG2细胞).
通过多维分子网络分析有氧运动对MAFLD的影响.
检查包括SESN家族,miRNA调节,AMPK,IL-6,Nrg4,PLIN5和Mfn-2在内的信号通路.

主要成果:

有氧运动通过SESN家族信号调节肝脏脂质代谢,胰岛素抵抗和抗氧化能力.
通过miRNA介导的途径和AMPK信号传递对于调节脂质生成和脂肪酸氧化至关重要.
运动抑制肝炎,优化脂质滴-线粒体相互作用,并抑制铁亡.

结论:

有氧运动通过复杂的网络调节能量代谢,应激反应和器官间通信来缓解MAFLD的进展.
已经澄清了关键的分子标和途径,支持运动在MAFLD中的治疗作用.
这些发现为未来针对性干预和MAFLD的药物开发提供了基础.

关键词:

这就是AMPKK.有氧运动是有氧运动.马夫尔德 (MAFLD) 是一个时间 SESNN 有治疗效果的治疗效果.

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