怀孕期间口腔保健以预防早产和低出生体重:随机对照试验的研究方案
Junko Yasuoka1, Yohei Takeshita2, Shunsuke Okada3
1Division of Global Health Sciences, Graduate School of Public Health, St. Luke's International University, Tokyo, Japan. yasuoka@slcn.ac.jp.
Trials
|December 9, 2025
概括
将牙周治疗与赫西丁口水相结合,可以显著降低孕妇早产和低出生体重的风险. 这种方法旨在改善母亲和婴儿健康结果.
科学领域:
- 产科和妇科 产科和妇科
- 牙周病学 牙周病学
- 公共卫生 公共卫生
背景情况:
- 孕期牙周病与早产 (PTB) 和低出生体重 (LBW) 等不良分娩结果有关.
- 标准的牙周治疗 (化和根平整 - SRP) 仅仅在预防这些结果方面取得了有限的成功.
- 新出现的证据表明,将SRP与赫西丁葡萄酸盐 (CHG) 口水相结合可能会将不良分娩结果的风险减半.
研究的目的:
- 评估SRP和CHG联合口水对改善孕妇分娩结果的协同效应.
- 在随机对照试验 (RCT) 中评估这种联合口腔健康干预措施的有效性.
主要方法:
- 一个多中心,三臂RCT涉及480名怀孕妇女在20周怀孕在孟加拉国.
- 患有牙周病的参与者随机分为SRP + CHG (干预) 或单独SRP (阳性对照).
- 没有牙周病的参与者被分配到负控制组. 主要结果:PTB率. 二次结果:出生时的体重,母亲的牙周状况,OHRQoL.
主要成果:
- 该部分是在研究完成后填写的.
结论:
- 结合SRP和CHG的口腔健康干预预计将提高分娩结果和母亲口腔健康.
- 证明有效性可以支持将口腔保健纳入孕产妇,新生儿和儿童健康战略,特别是在资源有限的环境中.
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