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德斯弗兰与异兰对接受腰部手术的老年人的早期认知功能的影响:一项随机临床试验

Danfeng Jin¹, Yuanyuan Ma¹, Yelong Ji¹

¹Department of Anesthesia, Zhongshan Hospital Fudan University, NO. 180, Fenglin Road, Shanghai, 200032, China.

BMC anesthesiology

|December 10, 2025

概括

与异氨酸相比,desflurane麻醉导致术后认知功能障碍 (POCD) 的发生率较低. 血液中的LINC01844基因表达可能作为检测POCD的生物标志物.

科学领域:

麻醉学麻醉学
神经科学是一个神经科学.
分子生物学分子生物学

背景情况:

手术后认知功能障碍 (POCD) 是挥发性麻醉剂的一个问题.
与isoflurane相比,desflurane对POCD的影响还没有很好地定义.
作为POCD的潜在生物标志物的LINC01844的作用需要进行研究.

研究的目的:

为了比较isoflurane和desflurane麻醉剂之间的早期术后认知功能.
探索LINC01844在外周血液中对POCD的诊断性能.

主要方法:

经历腰部手术的85名患者被随机分配给异黄素或脱黄素.
神经认知测试在手术前和手术后的1,3,5天进行.
使用定量实时聚合酶连锁反应测量LINC01844水平;通过Z-score方法诊断POCD.

主要成果:

在德斯弗兰组中,POCD的发病率明显较低 (p=0.001).
在手术后的德斯弗卢兰组中观察到较低的LINC01844水平 (p<0.001).
在术后第一,第三和第五天LINC01844水平升高与POCD相关 (p<0.001).

结论:

与isoflurane相比,desflurane对老年患者的早期术后认知功能的影响较小.
LINC01844表达不太受到德斯弗兰麻醉的影响.
周围血液中的相对LINC01844水平显示出POCD的潜在生物标志物.

关键词:

脱氨酸是什么? 脱氨酸是什么?诊断生物标志物的生物标志物.在这里,我们可以找到 LINC0184444 的链接.神经心理测试神经心理测试术后认知并发症术后认知并发症手术后的认知功能障碍

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