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语言复合物的开发,以提高对多个等离子体生物标记物的敏感性

Deling He¹, Rebecca E Langhough^2,3, Carol Van Hulle²

¹Department of Communication Sciences and Disorders, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association

|December 10, 2025

概括

一个经验语言组合有效地跟踪早期阿尔茨海默病 (AD) 的进展,使用连接的语音措施. 这种复合物对关键生物标志物具有高度敏感性,有助于精确检测和监测认知能力下降.

科学领域:

神经科学是一个神经科学.
语言学的语言学.
生物标志物研究生物标志物研究

背景情况:

语言缺陷是阿尔茨海默病 (AD) 的早期指标,但目前的评估缺乏连接语音分析,阻碍了早期检测和个性化干预.
现有的综合测量不能完全捕捉现实世界的沟通,限制了它们在识别与AD相关的微妙认知变化的实用性.

研究的目的:

开发和验证一个经验语言复合体,整合连接的语音,以敏感地检测早期的AD.
为了比较不同语言复合物的纵向灵敏度与神经退行症的血生物标志物.

主要方法:

分析了824名没有痴呆症的成年人的队列数据.
三种语言组合的构建:理论,连接的语音特定,和经验.
对血p-tau217,NfL和GFAP生物标志物的复合灵敏度的纵向比较.

主要成果:

经验语言复合体对所有三个等离子体生物标志物 (p-tau217,NfL,GFAP) 显示出优越和一致的敏感性.
特定的语言衰退模式出现了:正名回忆与p-tau217相关,而动物流利与NfL和GFAP相关.
经验组合,包括诸如单词/分钟和填充的暂停等措施,有效地捕获了整体认知-沟通性衰退.

结论:

一个经验语言复合提供了一个敏感的工具,用于检测和监测在早期的AD认知-沟通性下降.
个别的语言测量可能反映了特定生物标志物的特征,这表明语言和AD病理之间存在微妙的关系.
这些发现支持了血生物标志物和特定语言复合物的临床实用性,用于早期发现AD并跟踪疾病进展.

关键词:

阿尔茨海默病也是一种阿尔茨海默病.在GFAPAP中,GFAP是最重要的.在 NfL 中,它是NfL.类别流动性的流动性.连接的演讲连接的演讲.自己的名字自己的名字在p-tau217中

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