胸部癌症放射治疗后心血管相关死亡的风险
Zhaoyuan Zhang1,2,3, Dunchen Yao4, Rong Jiang1,3
1Cancer Center, The Tenth Affiliated Hospital, Southern Medical University (Dongguan People's Hospital), Dongguan, Guangdong, 510280, China.
Radiation oncology (London, England)
|December 10, 2025
概括
胸部放射治疗显著增加了心血管疾病的风险. 患有左下肺癌的患者面临心血管相关死亡 (CVRD) 的最高风险,需要有针对性的管理策略.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 辐射疗法 辐射疗法
背景情况:
- 胸部放射疗法的心脏毒性是一个重要的临床问题.
- 了解治疗后心血管疾病风险对于患者的治疗结果至关重要.
研究的目的:
- 评估胸部放射治疗后心血管相关死亡 (CVRD) 的风险.
- 为了比较不同胸部癌症治疗场所的CVRD风险.
- 开发一个CVRD风险的预测模型.
主要方法:
- 从接受放射治疗的胸部癌症患者 (2000-2020年) 的数据分析.
- 使用死亡率,细灰色模型,SMR,AER和Cox回归来评估CVRD.
- 在特定患者群体中开发CVRD风险的预测模型.
主要成果:
- 与一般人群相比,胸部放射治疗显著增加了心脏复发性心脏病的风险 (AER=28.59,SMR=2.37).
- 在右胸部与左侧相比,心肺复发风险较低,在左下肺与上肺相比,心肺复发风险较高.
- 在左下肺癌患者中,CVRD的预测模型表现良好 (C指数=0.67).
结论:
- 胸部放射治疗大大提高了心血管疾病的风险.
- 左下肺癌患者在放射治疗后表现出最高的CVRD风险.
- 开发的预测模型有助于管理和预测胸部恶性瘤中的CVRD风险.
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