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食道癌的营养风险指数的预后值:系统审查和元分析的方案
1Department of Radiotherapy, Nanjing Jiangning Hospital, Nanjing, China.
Medicine
|December 10, 2025
概括
营养风险指数 (NRI) 和老年营养风险指数 (GNRI) 是食道癌 (EC) 的重要预后指标. 高得分预测更好的生存率,而低得分与晚期疾病和转移相关.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 生物统计学 生物统计学
背景情况:
- 营养风险指数 (NRI) 和老年营养风险指数 (GNRI) 评估营养和炎症状况.
- 关于食道癌 (EC) 中NRI/GNRI预后价值的先前研究表明结果不一致.
- 缺乏在EC中对NRI和GNRI进行直接的元分析比较.
研究的目的:
- 为了评估NRI和GNRI在食道癌症的预后意义.
- 综合现有的关于NRI/GNRI对EC患者结果的预测价值的证据.
主要方法:
- 通过使用Embase,Web of Science,PubMed和Cochrane图书馆的研究进行了系统的元分析.
- 分析了包括2600名患者在内的10项研究的数据.
- 为了评估相关性,计算了聚合危险比率 (HR) 和相对比率 (RR).
主要成果:
- 高NRI/GNRI得分与改善的整体存活率 (HR=1.78) 和无转移存活率 (HR=1.95) 相关.
- 较低的NRI/GNRI得分与淋巴结转移的增加相关 (RR=1.18),更深的瘤入侵 (RR=1.18),以及晚期瘤阶段 (RR=1.32).
结论:
- 无论NRI和GNRI都是食道癌的独立预后因素.
- 将营养风险查纳入临床实践可以促进早期干预并提高治疗结果,特别是对于手术患者.
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