"血小板/淋巴细胞"和"中性粒细胞/淋巴细胞"的比例在患有风湿性心脏病的儿童中
Ecem İpek Altinok1, Emine Yurdakul Ertürk1, Taner Kasar2
1Department of Pediatrics, Faculty of Medicine, Ordu University, Ordu, Turkey.
Medicine
|December 10, 2025
概括
血小板/淋巴细胞比率 (PLR) 和中性粒细胞/淋巴细胞比率 (NLR) 在急性风湿性发烧 (ARF) 的儿童中升高. 较低的PLR与更严重的门疾病相关,这表明它有可能成为风湿性心脏病的预后生物标志物.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 类风湿病学 类风湿病学
- 炎症标记物 炎症标记物
背景情况:
- 急性风湿热 (ARF) 仍然是全球健康的一个重大问题,特别是在发展中国家.
- 炎症在ARF和其长期后果,风湿性心脏病的发病过程中起着关键作用.
- 中性细胞/淋巴细胞比率 (NLR) 和血小板/淋巴细胞比率 (PLR) 正在成为系统性炎症和心血管风险的可访问生物标志物.
研究的目的:
- 在被诊断为ARF的儿科患者中研究NLR和PLR的变化.
- 确定NLR和PLR是否可以预测ARF患者慢性风湿性心脏病的发展.
- 探索这些炎症标志物与心脏参与ARF的严重程度之间的关联.
主要方法:
- 对27名患有ARF的儿科患者和27名年龄和性别匹配的对照患者的医疗记录的回顾性审查.
- 分析全血细胞计数,包括白细胞,淋巴细胞,中性粒细胞和血小板水平.
- 在ARF患者和对照者之间计算和比较NLR和PLR,以及与临床发现的相关性,包括心炎和膜病变.
主要成果:
- 与对照组相比,ARF患者的白细胞计数,NLR和PLR显著增加 (分别P=.04,.001,.014).
- 在ARF组中,淋巴细胞数量显著减少 (P=.001).
- 心炎是普遍存在的 (85.2%),其中心肌吐是最常见的病变 (29.6%). 较低的PLR与严重的膜干扰显著相关 (P=.022),而NLR则没有 (P=.12).
结论:
- 升高的NLR和PLR,以及淋巴细胞数量的降低,是儿科ARF的特征.
- 在ARF患者中,PLR,但不是NLR,与膜心脏病的严重程度有显著的反相关性.
- 作为预测ARF儿童的长期心脏并发症的潜在预后生物标志物,PLR显示出有前途,需要在更大的队列中进一步调查.
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