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在斑块生物膜模型中,nHAP牙膏对细菌的影响

Xiudi Wang¹, Size Li¹, Yuanxu Li¹

¹Jiangsu Key Laboratory of Oral Diseases, Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu Province, China.

|December 10, 2025

概括

在实验室环境中,含有纳米亚帕 (nHAp) 的牙膏在治疗口腔细菌方面表现出显著的抗微生物疗效. 这种纳米-基亚帕提特牙膏有效地抑制了牙斑生物膜中的细菌生长.

科学领域:

口腔微生物学口腔微生物学
生物材料科学生物材料科学

背景情况:

牙斑生物膜是复杂的微生物群落,有助于口腔疾病.
了解新型牙膏成分的抗菌特性对于口腔健康至关重要.
纳米酸 (nHAp) 是牙科应用的一个有前途的生物材料.

研究的目的:

为了评估纳米-酸 (nHAp) 牙膏的抗菌疗效.
评估nHAp牙膏在体外斑块生物膜模型中对口腔细菌的影响.
为了确定nHAp对生物膜酸性和细菌负载的影响.

主要方法:

使用 Porphyromonas gingivalis 和 Streptococcus mutans 在人类质牙膜盘上构建了一个双种体外斑块生物膜模型.
在96小时内将生物膜暴露在nHAp牙膏溶液中,监测pH值变化.
量化了细菌数量,并进行了扫描电子显微镜 (SEM) 和共聚焦激光扫描显微镜 (CLSM) 进行生物膜评估.

主要成果:

nHAp牙膏在培养基的pH值下降最少,这表明酸性降低.
细菌计数显示,nHAp组的细菌负载明显较低.
显微镜评估 (SEM和CLSM) 证实了nHAp牙膏的优越抗菌作用和生物膜抑制.

结论:

含有纳米酸 (nHAp) 的牙膏在体外对口腔细菌表现出显著的抗菌活性.
在牙斑生物膜模型中,nHAp有效抑制细菌生长和酸生产.
这些发现表明,nHAp牙膏具有预防和管理牙周病的潜力.

关键词:

抗微生物药物是一种抗菌药物.细菌是一种细菌.纳米-氧亚帕提特是一种纳米-氧亚帕提特.牙周周节牙周节牙周节牙斑块生物薄膜 - 生物薄膜牙膏是一种牙膏.

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