压力高血糖比率 (SHR) 与动脉硬度的关联:一个横截面研究
Lele Chen1,2, Peng Tian3, Yaying Xu4
1Department of Interventional and Vascular Surgery of Xincai County People's Hospital, Zhumadian, Henan, China.
Medicine
|December 10, 2025
概括
压力高血糖比率 (SHR) 与美国成年人的动脉硬度增加有关. 这种关联甚至在肥胖,糖尿病或癌症患者中也被观察到.
科学领域:
- 心血管健康 心血管健康
- 代谢综合征是代谢综合征的一种.
- 临床生物标志物 临床生物标志物
背景情况:
- 压力高血糖比 (SHR) 是压力期间葡萄糖失调的标志物,与不良临床结果有关.
- 动脉硬性是心血管事件的预测因素,以前没有与SHR相关的研究.
- 了解心血管疾病的新风险因素对于公共卫生至关重要.
研究的目的:
- 为了研究压力高血糖比率 (SHR) 和动脉硬之间的关联.
- 通过使用国家调查数据,在大量多样化的美国成年人群中探索这种关系.
主要方法:
- 对2005-2018年国家健康和营养检查调查 (NHANES) 数据的分析.
- 使用禁食血葡萄糖和HbA1c计算SHR的计算.
- 通过估计的脉冲波速度 (ePWV) 和统计建模 (加权线性/逻辑回归,RCS) 来评估动脉硬度.
主要成果:
- SHR与ePWV (连续和升级措施) 独立且积极相关.
- 在SHR和ePWV之间观察到非线性和线性关系.
- 在超重/肥胖,糖尿病和癌症患者小组中,这种关联略有减弱.
结论:
- 在美国成年人中,SHR和动脉硬之间存在独立的积极关联.
- SHR可以作为动脉硬性和相关心血管风险的潜在指标.
- 需要进一步的前性研究来证实这些发现并探索临床影响.
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