在美国成年人样本中,每周睡眠时间和胆结石之间的关联:一个横截面研究
Jian Xu1, Zhi-Xiang Xu2, Kang-Pei Yan3
1Department of Gastroenterology, The People's Hospital of Danyang, Affiliated Danyang Hospital of Nantong University, Zhenjiang, Jiangsu Province, China.
睡眠时间较长与美国成年人胆结石风险较低有关. 这种关联在男性和高胆固醇血症患者中特别强,突出了睡眠.
科学领域:
- 流行病学 流行病学
- 胃肠病学 胃肠病学
- 睡眠医学 睡眠医学
背景情况:
- 胆结石病和睡眠障碍是普遍存在的公共卫生问题.
- 每周睡眠时间和胆结石风险之间的关系尚未得到充分证实.
研究的目的:
- 研究美国成年人每周睡眠时间与胆结石风险之间的关联.
- 探索基于性别和高胆固醇血清症状况的潜在亚组差异.
主要方法:
- 使用国家健康和营养检查调查 (NHANES,2021-2023) 的数据进行横截面研究.
- 参与了3897名成年参与者.
- 使用高级多变量回归,平滑曲线拟合和值效应分析,并对混因素进行调整.
主要成果:
- 观察到胆结石的患病率为6.04%.
- 每周睡眠时间与胆结石风险有显著的反向关联 (调整后OR=0.961,95%CI:0.942-0.981).
- 这种反向关联在性别和高胆固醇血症亚组中一致,确定了细分关系.
结论:
- 增加每周睡眠时间与美国成年人的胆结石发病率降低有关.
- 睡眠时间对胆结石风险的保护作用在男性和高胆固醇血症患者中更为明显.
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