Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

The relationship between family socioeconomic status and cultural background on the career self-determination of Chinese and Kazakhstani students.

Frontiers in psychology·2026
Same author

Dual resistance to asparaginase and PD-1 blockade in extranodal natural killer/T-cell lymphoma: dismal outcomes from a multicenter cohort.

Haematologica·2026
Same author

Clinical significance of high-density lipoprotein cholesterol and its dynamic change in patients with lymphoma-associated hemophagocytic lymphohistiocytosis.

Therapeutic advances in medical oncology·2026
Same author

Neutrophil extracellular traps in thrombosis of hematologic malignancies: Underlying mechanisms and therapeutic opportunities (Review).

International journal of molecular medicine·2026
Same author

Heterogeneous and nonlinear associations between depressive symptoms and functional disability in older Chinese adults.

BMC psychology·2026
Same author

Mume Fructus Total Flavonoids Modulate miR-145-3p Expression to Inhibit Lipopolysaccharide-induced Inflammatory Cytokine Production in BV2 Cells.

Combinatorial chemistry & high throughput screening·2026

相关实验视频

Updated: Jan 9, 2026

Enhancing Tumor Content through Tumor Macrodissection
10:04

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

12.0K

卡塞普辛对扩散大B细胞淋巴瘤风险的影响:孟德尔的随机化研究

Chuanyang Lu1,2,3, Qiuni Chen1,2,3, Yuye Shi1,2,3

  • 1Department of Hematology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, Jiangsu Province, China.

Medicine
|December 10, 2025
PubMed
概括

这项研究发现,升高的甲素S (CTSS) 水平因果上会增加扩散大B细胞淋巴瘤 (DLBCL) 的风险. 需要进一步的研究来了解机制,并为DLBCL患者开发新的治疗方法.

关键词:
门德尔的随机化在 cathepsin 中.扩散大的B细胞淋巴瘤.仪器变体 仪器变体单个核酸的多形态.

更多相关视频

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
11:35

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA

Published on: August 21, 2016

13.4K
Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation
11:06

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation

Published on: September 20, 2017

6.5K

相关实验视频

Last Updated: Jan 9, 2026

Enhancing Tumor Content through Tumor Macrodissection
10:04

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

12.0K
Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
11:35

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA

Published on: August 21, 2016

13.4K
Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation
11:06

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation

Published on: September 20, 2017

6.5K

科学领域:

  • 生物化学 生物化学
  • 在瘤学瘤学.
  • 遗传学 是一个遗传学.

背景情况:

  • 甲素越来越多地与各种疾病有关,包括固体瘤和血液恶性瘤.
  • 甲素和恶性淋巴瘤之间的因果关系尚不清楚,需要进一步调查.

研究的目的:

  • 通过使用孟德尔的随机化方法,研究甲素对患恶性淋巴瘤的风险的潜在因果作用.
  • 具体来说,要确定cathepsin S (CTSS) 是否在扩散性大B细胞淋巴瘤 (DLBCL) 中起因作用.

主要方法:

  • 采用两样本的孟德尔随机化 (MR) 分析,使用全基因组关联研究 (GWAS) 数据集来分析甲素和淋巴瘤.
  • 选单个核酸多态 (SNPs) 进行全基因组意义和链接不平衡.
  • 进行了敏感性分析和逆向MR,以确保研究结果的稳定性和有效性.

主要成果:

  • 基因预测的升高的甲素S (CTSS) 水平与扩散型大B细胞淋巴瘤 (DLBCL) 的风险增加有显著的积极关联.
  • 患有较高CTSS水平的患者患DLBCL的风险增加了20.6%.
  • 对于其他甲素,没有确立因果关系,也没有检测到DLBCL和CTSS之间的反向因果关系.

结论:

  • 这项研究提供了证据表明,CTSS对扩散型大B细胞淋巴瘤 (DLBCL) 的发展有因果作用.
  • 需要进一步的研究来阐明潜在的生物机制,并探索针对CTSS进行DLBCL治疗的新型治疗策略.