Search research articles

关于 JoVE

概览领导团队博客 JoVE 帮助中心

作者

出版流程编辑委员会范围与政策同行评审常见问题投稿

图书馆员

用户评价订阅访问资源图书馆顾问委员会常见问题

研究

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments 存档

教育

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual 教师资源中心教师网站

使用条款与条件

相关概念视频

Regulation of Angiogenesis and Blood Supply

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序

Same author

Considerations to Better Meet the Needs of People Living With Diabetes While in Prison or Detention.

Diabetes spectrum : a publication of the American Diabetes Association·2024

Same author

A Pragmatic Rethinking of Glucose Monitoring for the Incarcerated.

Diabetes spectrum : a publication of the American Diabetes Association·2024

Same author

Detection of fluorescent protein mechanical switching in cellulo.

Cell reports methods·2024

Same author

Neurogenic Cell Behavior in 3D Culture Enhanced Within a Highly Compliant Synthetic Hydrogel Platform Formed via Competitive Crosslinking.

Cellular and molecular bioengineering·2024

Same author

Antibiotic exposure is associated with decreased risk of psychiatric disorders.

Frontiers in pharmacology·2024

Same author

Detection of Fluorescent Protein Mechanical Switching in Cellulo.

bioRxiv : the preprint server for biology·2024

Search research articles

相关实验视频

Updated: Jul 6, 2026

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

Published on: August 28, 2014

水凝生物材料用于支持和引导血管化.

Rachel Chapla¹, Jennifer L West¹

¹Department of Biomedical Engineering, Duke University, Durham, NC, United States of America.

Progress in biomedical engineering (Bristol, England)

|December 10, 2025

概括

生物活性生物材料,特别是水凝,被设计为指导血管化,用于组织修复和疾病治疗. 了解细胞矩阵相互作用是设计促进血管形成的有效材料的关键.

科学领域:

生物材料科学生物材料科学
再生医学是一种再生医学.
组织工程是组织工程.

背景情况:

血管化对于工程器官和治疗缺血性疾病至关重要.
了解血管生成和血管生成中的细胞和分子事件对于生物材料设计至关重要.
生物材料平台可以模仿体内细胞矩阵和信号相互作用,以促进血管化.

研究的目的:

审查目前用于血管化的水凝材料.
讨论水凝的创新设计修改,以指导和支持血管化.
突出水凝特性在促进血管细胞组合和管体生成方面的重要性.

主要方法:

对天然衍生和合成水凝基的审查.
对机械性能,生物降解,细胞粘附和生物化学信号的水凝修饰的分析.
检查影响血管细胞行为的建筑性质.

主要成果:

水凝具有可调节的特性 (软度,水分,生物惰性),适用于血管化应用.
具有特定的机械,降解,粘合剂,信号和建筑特征的定制水凝促进了血管化.
设计修改允许精确控制细胞物质相互作用,以引导血管网络形成.

关键词:

在PEGDA的基础上,PEGDA是PEGDA.血管新生是因为血管新生.原蛋白凝凝是一种凝.纤维素凝是一种纤维素凝.石版印刷石版印刷石版印刷微流体学在微流体学方面血管生成是一种血管形成的过程.

更多相关视频

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

Author Spotlight: Automated Bioprinting for High-Throughput Vascular Model Fabrication

Author Spotlight: Automated Bioprinting for High-Throughput Vascular Model Fabrication

Published on: August 16, 2024

相关实验视频

Last Updated: Jul 6, 2026

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

Published on: August 28, 2014

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

Author Spotlight: Automated Bioprinting for High-Throughput Vascular Model Fabrication

Author Spotlight: Automated Bioprinting for High-Throughput Vascular Model Fabrication

Published on: August 16, 2024

结论:

水凝是设计支持血管化的生物活性生物材料的多功能平台.
创新的水凝设计对于引导再生医学中的血管生成和血管生成至关重要.
对生物材料-细胞相互作用的进一步研究将促进血管相关疾病的治疗.