查看直接向消费者提供的抑郁风险遗传测试结果在心理上是可以容忍的:从纵向等价性研究中得到的证据
Rebecca M K Berns1, Devika Dhamija1, Daniella Coker1
123andMe Research Institute, Palo Alto, CA, USA.
HGG advances
|December 10, 2025
概括
在现实研究中,接受抑郁症多基因风险评分 (PRS) 没有显著影响抑郁症或焦虑症状. 抑郁症的遗传风险信息被参与者容忍得很好.
科学领域:
- 精神病学遗传学 精神病学遗传学
- 临床心理学 临床心理学
背景情况:
- 对抑郁症的多基因风险评分 (PRS) 越来越多.
- 在现实环境中接受抑郁症PRS结果的心理影响在很大程度上是未知的.
研究的目的:
- 量化接受风险抑郁症PRS对抑郁和焦虑症状的心理影响.
主要方法:
- 对23andMe研究参与者的长度前性队列研究 (n=917).
- 与那些没有 (n=556) 看到他们风险抑郁症PRS (n=361) 的个人进行了比较.
- 使用线性回归和等效测试,评估结果暴露前和后的抑郁症 (PHQ-8) 和焦虑症 (DASS-21) 症状.
主要成果:
- 在观看和不观看他们的PRS的组之间,抑郁或焦虑症状得分的变化没有统计学上显著的差异.
- 经过调整后的组间差异:抑郁症 -0.17分 (90% CI -0.59至0.24),焦虑症 -0.092分 (90% CI -0.35至0.17).
- 结果在各个子组中一致,包括那些有或没有以前抑郁或焦虑的人.
结论:
- 暴露于抑郁症的PRS结果在遗传风险人群中在现实环境中被很好地容忍.
- 接受抑郁症遗传风险信息似乎不会对心理健康症状产生不利影响.
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