在糖尿病中对SARS-CoV-2疫苗接种的IL-10和IL-13-偏差T细胞反应
Emma M Jones1, Caren Sourij2, Martin Stradner3
1Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK.
European journal of immunology
|December 10, 2025
概括
1型和2型糖尿病患者接种疫苗显示T细胞反应受损. 糖尿病会影响T细胞的记忆和功能,这可能会影响针对SARS-CoV-2等感染的疫苗有效性.
科学领域:
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
- 病毒学 病毒学
背景情况:
- 1型和2型糖尿病增加了来自呼吸道病毒的风险.
- 接种疫苗通常会增强健康个体的T细胞反应.
- 疫苗在糖尿病患者群体中的有效性尚不清楚.
研究的目的:
- 研究1型和2型糖尿病患者的疫苗特异性T细胞反应.
- 在糖尿病人和非糖尿病人之间比较T细胞大小,记忆力和针对SARS-CoV-2疫苗接种的功能.
主要方法:
- 研究了SARS-CoV-2疫苗接种后的CD4+和CD8+T细胞反应.
- 评估T细胞的记忆维护和功能.
- 在疫苗特异性T细胞中比较了细胞因子 (IL-10,IL-13) 概况.
主要成果:
- 糖尿病患者表现出CD4+和CD8+T细胞记忆维护中的缺陷.
- 糖尿病患者的疫苗特异性T细胞显示功能降低.
- 具有可检测的T细胞的糖尿病患者表现出具有增加IL-10和IL-13的宽容性表型.
结论:
- 糖尿病会损害疫苗诱导的T细胞记忆和功能.
- 在糖尿病中观察到的T细胞表型可能会影响免疫对疫苗接种的反应.
- 研究结果表明,需要重新考虑糖尿病患者的疫苗接种策略.
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